YeastMRXdeletions have short chronological life span and more triacylglycerols
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چکیده
منابع مشابه
Quantifying yeast chronological life span by outgrowth of aged cells.
The budding yeast Saccharomyces cerevisiae has proven to be an important model organism in the field of aging research. The replicative and chronological life spans are two established paradigms used to study aging in yeast. Replicative aging is defined as the number of daughter cells a single yeast mother cell produces before senescence; chronological aging is defined by the length of time cel...
متن کاملChronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.
Mutations in RAS2, CYR1, and SCH9 extend the chronological life span in Saccharomyces cerevisiae by activating stress-resistance transcription factors and mitochondrial superoxide dismutase (Sod2). Here we show that mutations in CYR1 and SCH9 also extend the replicative life span of individual yeast mother cells. However, the triple deletion of stress-resistance genes MSN2/MSN4 and RIM15, which...
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The TORC1 and PKA protein kinases are central elements of signaling networks that regulate eukaryotic cell proliferation in response to growth factors and/or nutrients. In yeast, attenuation of signaling by these kinases following nitrogen and/or carbon limitation activates the protein kinase Rim15, which orchestrates the initiation of a reversible cellular quiescence program to ensure normal c...
متن کاملTwo-carbon metabolites, polyphenols and vitamins influence yeast chronological life span in winemaking conditions
BACKGROUND Viability in a non dividing state is referred to as chronological life span (CLS). Most grape juice fermentation happens when Saccharomyces cerevisiae yeast cells have stopped dividing; therefore, CLS is an important factor toward winemaking success. RESULTS We have studied both the physical and chemical determinants influencing yeast CLS. Low pH and heat shorten the maximum wine y...
متن کاملMitochondrial Dysfunction Increases Oxidative Stress and Decreases Chronological Life Span in Fission Yeast
BACKGROUND Oxidative stress is a probable cause of aging and associated diseases. Reactive oxygen species (ROS) originate mainly from endogenous sources, namely the mitochondria. METHODOLOGY/PRINCIPAL FINDINGS We analyzed the effect of aerobic metabolism on oxidative damage in Schizosaccharomyces pombe by global mapping of those genes that are required for growth on both respiratory-proficien...
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ژورنال
عنوان ژورنال: FEMS Yeast Research
سال: 2015
ISSN: 1567-1364,1567-1364
DOI: 10.1093/femsyr/fov109